SCINTIGRAPHIC EVALUATION OF FOUR DOGS WITH PROTEIN‐LOSING ENTEROPATHY USING111INDIUM‐INDIUM‐LABELED TRANSFERRIN

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Abstract
The purpose of this sutdy was to determine the clinical utility of 111 In‐labeled transferrin (111 In‐TF) scintigraphy for evaluating dogs suspected of having protein‐losing enteropathies. Four dogs were injected intravenoulsy with autologous 111In‐TF after 30 min incubation (at 37°C) of 18.5 MBq (0.5mCi) 111In CI3 with one ml of autologous plasma, Serial right lateral, left lateral and dorsal images were obtained 2, 4, and 24 hours post 111 In‐TF administration, Images were subjectively evaluated for the presence or absence of 111 within the gastrointestinal tract. The results of total protein, albumin and globulin legels and results form gastrointestinal tract. the results of total protein, albumin and globulin levels and results from gastrointestinal biopsies were recorded. In one dog, a follow‐up scientigraphic study was done six months after initial evaluation and initiation of treatment for plasmocytic‐lymphocytic enteritis. Gastrointestinal activity was noted by two hours in two dogs, while all four dogs had gastrointestinal activity on the 24 hour images. The mean (±std dev) plasma protein, albumin and globulin levels were 3.5 (±0.9), 1.7 (±1) and 1.8 (±0.3) respectively at the time of initial presentation. In the one dog that was evaluated after therapy, faint visualization of radioactivity within the colon was noted on the 24 hour image. Based on this study, 111In‐TF appears to be a viable scientigraphic method for evaluating dogs with suspected dogs withfd suspected protein‐losing enteropathies, Potential limitations of tjis radiopharmaceutical include cost and prolonged isolation of the animal prior to release to the client due to the long physical half‐life (T½= 2.82 days).