Autoantibody to U3 Nucleolar Ribonucleoprotein (Fibrillarin) In Patients with Systemic Sclerosis
- 1 January 1992
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 35 (1) , 95-100
- https://doi.org/10.1002/art.1780350114
Abstract
To determine the clinical significance of serum antibodies to the U3 small nuclear ribonucleoprotein particle ([U3]snRNP), we studied sera from 416 patients with systemic sclerosis (SSc) and 264 controls, using immunofluorescence and immunoprecipitation assays. The presence of serum anti‐(U3)snRNP was highly specific to SSc, was found more frequently in blacks, and was associated with skeletal muscle disease and primary pulmonary arterial hypertension. These antibodies may identify one or more unusual clinical subsets of SSc.Keywords
This publication has 17 references indexed in Scilit:
- cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.Proceedings of the National Academy of Sciences, 1991
- Autoantibody to th ribonucleoprotein (nucleolar 7–2 rna protein particle) in patients with systemic sclerosisArthritis & Rheumatism, 1990
- Clinical association of autoantibodies to fibrillarin with diffuse scleroderma and disseminated telangiectasiaPublished by Elsevier ,1990
- The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assaysArthritis & Rheumatism, 1990
- The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processingCell, 1990
- Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.Proceedings of the National Academy of Sciences, 1989
- Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell BiologyPublished by Elsevier ,1989
- Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma)Arthritis & Rheumatism, 1988
- Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosisArthritis & Rheumatism, 1988
- Preliminary criteria for the classification of systemic sclerosis (scleroderma)Arthritis & Rheumatism, 1980