Ineffectiveness of Sulfonylureas in Alloxan Diabetic Rats.
- 1 March 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 91 (3) , 475-477
- https://doi.org/10.3181/00379727-91-22297
Abstract
The oral administration of 1-3-butyl-p-tolylsulfonylurea to normal rats results in a marked hypo-glycemia within 1 hour which persists for 4 hours. No significant change occurs in the blood sugar of similarly treated alloxan diabetic rats. The hypoglycemic action of the sulfonylurea is attributed to the inhibition of insulin destruction by insulinase.Keywords
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