Stereocontrolled Addition Reaction of Organometallics to Chiral α-Keto Amides
- 1 July 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 63 (7) , 1894-1897
- https://doi.org/10.1246/bcsj.63.1894
Abstract
Complementary stereoselection in the addition reaction of several organometallics to chiral benzoylformamide, prepared from benzoylformic acid and (S)-2-(methoxymethyl)pyrrolidine, could be achieved using magnesium- and titanium-based reagents to give differeent diastereomers of atrolactamide. On the other hand, the reaction of phenyl metallics to the corresponding pyruvamide afforded (S)-atrolactamide.Keywords
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