Clinical efficacy of desmopressin acetate for hemostatic control in patients with primary platelet disorders undergoing surgery
- 1 February 1987
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 24 (2) , 215-219
- https://doi.org/10.1002/ajh.2830240213
Abstract
Desmopressin acetate (DDAVP) is efficacious in patients with von Willebrand's disease. It additionally appears to have value in patients with uremic or aspirininduced platelet dysfunction. We report here three patients with primary platelet defects who had previously experienced grossly inadequate hemostasis to whom we administered DDAVP. Each successfully underwent surgical procedures with DDAVP as the only hemostatic agent. Although the mechanism of these salutary effects is unclear, DDAVP may exert an influence directly on the endothelium independent of correcting abnormalities of the factor VIII: von Willebrand complex associated with von Willebrand's disease.Keywords
This publication has 10 references indexed in Scilit:
- Drugs Five Years Later: DesmopressinAnnals of Internal Medicine, 1985
- Response of Patients with Mild and Moderate Hemophilia A and von Willebrand's Disease to Treatment with DesmopressinAnnals of Internal Medicine, 1985
- DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendotheliumBlood, 1984
- SHORTENING OF BLEEDING TIME BY 1-DEAMINO-8-D-ARGININE VASOPRESSIN IN VARIOUS BLEEDING DISORDERSThe Lancet, 1984
- DDAVP ENHANCES PLATELET ADHERENCE AND PLATELET AGGREGATE GROWTH ON HUMAN ARTERY SUBENDOTHELIUM1984
- DDAVP: Does the drug have a direct effect on the vessel wall?Thrombosis Research, 1983
- Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypesBlood, 1982
- MULTIMERIC COMPOSITION OF FACTOR-VIII VONWILLEBRAND-FACTOR FOLLOWING ADMINISTRATION OF DDAVP - IMPLICATIONS FOR PATHO-PHYSIOLOGY AND THERAPY OF VONWILLEBRANDS DISEASE SUBTYPES1982
- Variant von Willebrand's DiseaseJournal of Clinical Investigation, 1980
- Aggregation of Blood Platelets by Adenosine Diphosphate and its ReversalNature, 1962