Selective Functionalization of Calix[6]arenes at the Upper Rim
- 1 January 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1994 (01) , 47-50
- https://doi.org/10.1055/s-1994-25403
Abstract
Methylation of partially O-benzylated p-tert-butylcalix[6]arenes followed by hydrogenolysis constitutes an efficient method for the preparation of partially O-alkylated Calix[6]arenes in gram amounts, without adhering to column chromatography separations. Selective de-tert-butylation followed by halogenation, or ipso-nitration of these precursors affords Calix[6]arenes containing bromo- or nitrosubstituents, respectively, at precise positions of the upper rim.Keywords
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