ANALYSIS OF ELECTROPHORETIC MOBILITY HISTOGRAM OF MOUSE THYMOCYTES DURING TUMOR-DEVELOPMENT

  • 1 January 1984
    • journal article
    • research article
    • Vol. 52  (2) , 359-365
Abstract
The population of medullary thymocytes without peanut agglutinin (PNA) receptor consisted of 2 groups: Lyt-1+.2- cells with a high mobility of 1.0 .mu./s per V per cm, and Lyt-1+.2+ cells with a low mobility of 0.7 .mu.m/s per V per cm. Also used were cortical thymocytes with PNA receptor: these were Lyt-1+.2+ cells, having low mobility. In C3H/He mice bearing plasmacytoma X5563, a low mobility peak appeared in the histograms of peripheral lymphocytes. A high mobility peak appeared in the histograms of thymocytes. Using fully automated analytical instrumentation, it was determined that the appearance of high mobility cells during tumor growth strongly correlated with the decreased proportion of low mobility cells in thymus.