Immunopathology of Follicular Lymphomas

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Abstract
To the Editor: In their article in the March 2 issue of the Journal Warnke and Levy propose that reactive lymphoid follicles can be differentiated from lymphoma nodules by the characterization of immunoglobulin light chains in direct immunofluorescence. There are several arguments against this approach.First of all, some lymphomas may be biclonal rather than monoclonal.1 For example, we recently studied a lymphoid lung mass from a patient with well differentiated lymphocytic lymphoma containing two populations of cytologically identical cells: one consisted of IgMκ cells that formed EA but not EAC rosettes, and the other IgGλ cells positive for EAC . . .