METASTASIS AND TUMOR IMMUNITY
Open Access
- 19 November 1910
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 55 (21) , 1805
- https://doi.org/10.1001/jama.1910.04330210033010
Abstract
In a previous article,1I have reported some observations on a sarcoma of the chicken, a typical neoplasm, which, unlike the avian tumors already studied, has shown itself transplantable from fowl to fowl. At this writing the sarcoma has developed an extraordinary malignancy and gives wide-spread metastasis. Work with it has brought out facts which bear largely on the general problem of tumor metastasis and tumor immunity. The sarcoma has passed through six generations of inoculated fowls during the last thirteen months. It is of spindle-celled variety and has throughout remained true to type. In the degenerated portions true mucin may be found. The specificity which at first limited its successful transmission to fowls of the same pure-bred stock in which the growth arose has been to some extent overcome. It now grows in about 85 per cent. of these pure-bred fowls—light, barred Plymouth Rocks—and in an occasional individual thatKeywords
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