THE EFFECT OF PRAZOSIN ON PRE‐ AND POSTSYNAPTIC α‐RECEPTORS IN THE PITHED RAT

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Abstract
SUMMARY: 1. Prazosin had a marked inhibitory effect on post‐synaptic a‐receptors in the pithed rat, as measured by the blood pressure response to the cumulative administration of clonidine.2. Prazosin had no inhibitory effect, however, on the pre‐synaptic a‐receptor, as measured by the clonidine‐induced reduction in the tachycardia produced by stimulation of the cardiac nerves.3. These results suggest that prazosin has a selective antagonistic affinity for post‐synaptic a‐receptors.