A matrix method for calculating recurrence risks of unilocal disorders for genetic counselling
- 1 July 1976
- journal article
- research article
- Published by Wiley in Annals of Human Genetics
- Vol. 40 (1) , 25-36
- https://doi.org/10.1111/j.1469-1809.1976.tb00162.x
Abstract
A matrix method to calculate conditional likelihoods in a pedigree and use them to determine recurrence risks for unilocal disorders in [human] genetic risks is presented. Different matrices are assigned to individual members of the pedigree and combined into matrix expressions. The method is explained for X-linked recessive conditions and autosomal dominant conditions with incomplete penetrance.This publication has 4 references indexed in Scilit:
- The ENCU scoring systemClinical Genetics, 1971
- The Ensu scoring system in genetic counsellingAnnals of Human Genetics, 1970
- Incomplete penetrance and the ascertainment of recessive characters in man-I: Introduction and distribution theoryJournal of Chronic Diseases, 1970
- The Application of Bayesian Methods in Genetic CounsellingHuman Heredity, 1969