SEX DEPENDENCE OF METABOLIC ACTIVATION INVITRO OF MYCOHEPATOCARCINOGEN AFLATOXIN-B1

  • 1 January 1976
    • journal article
    • research article
    • Vol. 7  (1) , 1-12
Abstract
Using liver microsomes, metabolic activation of aflatoxin B1, determined by the formation of DNA- and protein binding metabolites, was studied to elucidate the possible basis underlying sex differences in sensitivity of male and female rats to aflatoxin B1. Male rats, which are more sensitive to AFB1, produced significantly higher amounts of these metabolites than female rats. Castration of males reduced the level to that of females, whereas ovariectomy was without any effect.

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