Exophthalmos in Hypophysectomized and Cortisone-Treated Albino Rats

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Abstract
Marked exophthalmos develops in rats hypophysectomized at about a month of age and in weanling rats given cortisone in sufficient doses to arrest body growth. The rate of growth of the eyes is about the same as that of the eyes of control rats. In both instances the exophthalmos results from a disparity between the size of the eye and the size of the orbital space. Since the eye continues to grow while the orbital space remains relatively unchanged, the eye must of necessity protrude. The fact that growth of the eye is independent of the growth hormone of the hypophysis has not been explained.

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