Magnitude and Nature of Residues in Tissues and Eggs of Poultry Receiving Ruelene in the Feed1

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Abstract
Ruelene® (4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate) was rapidly metabolized by laying hens receiving the compound in the diet for 7 days at 100 p.p.m. Acetonitrile-soluble residues were dissipated from several tissues by the time the hens were returned to normal feed for 3 days, but appeared in egg yolks at 3 to 5 days after the hens were returned to normal feed. These acetonitrile-soluble residues were not characterized as Ruelene. Ruelene was degraded to phosphoric acid that was incorporated into normal phosphorus-containing constituents, particularly in bone tissue. Only 29% of the Ruelene consumed in the feed was eliminated in the feces during the 21-day experimental period. Six metabolites were isolated from the excreta and there was a possibility that nine metabolites were present. O-methyl phosphoric acid and 4-tert-butyl-2-chlorophenyl methyl phosphoric acid were tentatively identified. The in vivo degradation of Ruelene is complex, involving enzymatic attack at the three different groupings of the molecule.

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