PHARMACOKINETICS OF HEPATOBILIARY IMAGING AGENTS IN RATS - CONCISE COMMUNICATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 20  (1) , 45-49
Abstract
The distribution and elimination kinetics of 99mTC pyridoxylidene glutamate (Tc-99m PG), of 99mTC N-(2,6-dimethyl-phenylcarbamoylmethyl) iminodiacetic acid (99mTC HIDA), and of 131I rose bengal in blood were quantitated after i.v. injection in rats. This was performed by use of a unique indwelling catheter than externalizes the systemic circulation, permitting continuous monitoring of blood radioactivity. The blood activity-time curves of 99mTC PG and 99mTC HIDA are described by the sum of 3 exponential functions. Only 2 exponentials are required in the case of 131I rose bengal. The rank order for the rates of loss from blood was 99mTC HIDA > 99mTC PG > 131I rose bengal. Bile was collected after administration of 99mTC HIDA and 99mTC PG. The total excretion of radioactivity over a 70 min period amounted to 65.7% and 42.8% of the dose of 99mTC HIDA and 99mTC PG, respectively. A linear compartmental kinetic model was developed to account for the disappearance from blood and the biliary excretion of these radiopharmaceuticals in rats.

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