Morphine: Conditioned Increases in Self-Administration in Rhesus Monkeys

Abstract
Operant responding in three monkeys was maintained by intravenous presentations of morphine. Nalorphine produced reliable increases in morphine-reinforced responding. With successive daily nalorphine injections there was adecreased latency of self-administration responding for morphine, and substituted saline injections produced conditioned increases in morphine-reinforced responding.

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