Apolipoprotein C-lll gene variation and dyslipidaemia
- 1 June 1997
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 8 (3) , 154-158
- https://doi.org/10.1097/00041433-199706000-00005
Abstract
Within the apolipoprotein A-I-C-III-A-IV gene cluster, the Sstl polymorphism in the 3' untranslated region of the apolipoprotein C-lll gene is the variant site most consistently and strongly associated with raised plasma triglyceride levels and coronary artery disease. To date the molecular mechanisms that underlie this effect have not been fully identified and variation within the insulin-responsive element of the apolipoprotein C-lll proximal promoter cannot entirely explain the Sstl effect.Keywords
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