PROSPECTIVE EXPERIENCE WITH MATERNAL RUBELLA AND THE ASSOCIATED CONGENITAL MALFORMATIONS

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Abstract
The Fetal Life Study (1946-1959) recorded 25 instances of rubella infection during pregnancy. Exposure to rubella occurred during 95 other pregnancies. The results of these pregnancies and the follow-up of the infants is reported. A summary of other prospective studies reported in the literature is also presented. The incidence and number of malformations per live-born child are discussed in relation to the time of maternal rubella during pregnancy. There appeared to be a decreasing risk of malformation in live-born infants from 47% (8/17) in the first 4 weeks, 22% (8/36) in the fifth through eighth weeks, to 7% (3/46) in the ninth through twelfth weeks. Although the trend appears to be definite, the Fetal Life Study and the six other studies summarized are quite diverse and the samples are small. It is suggested that prospective observations be more completely reported and control observations also be made. There is dire need of objective laboratory techniques for the diagnosis of rubella.

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