Sensing Cellular Stress: Another New Function for the Nucleolus?
- 16 March 2004
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science's STKE
- Vol. 2004 (224) , pe10
- https://doi.org/10.1126/stke.2242004pe10
Abstract
Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.Keywords
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