THE EFFECTS OF HORMONES AND OTHER AGENTS ON WEIGHT CHANGES AND ON CEROID DEPOSITION INDUCED BY OESTROGEN ADMINISTRATION AND BY HYPOPHYSECTOMY IN THE ADRENAL GLANDS OF BALB/c Crgl MICE

Publisher Website
Google Scholar
Abstract
Male and female mice were gonadectomized. Estrogen administration induced adrenal hypertrophy in both sexes, but thyroxine augmented the effect only in the female. Cortisol, androgen, and progesterone abolished or inhibited the estrogen effect. Hypophysectomized-gonadectomized mice showed adrenal atrophy, which was counteracted by corticotropin. Estrogen also induced ceroid deposition in gonadectomized mice. This could be inhibited by corticotropin, androgen, or progesterone. Ceroido-genesis was most marked in the hypophysectomized-gonadectomized female and was even augmented by testosterone or progesterone.