LACK OF DONOR-SPECIFIC TOLERANCE IN MICE WITH ESTABLISHED ANTI-Ia-TREATED ISLET ALLOGRAFTS12
- 1 December 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 36 (6) , 691-694
- https://doi.org/10.1097/00007890-198336060-00021
Abstract
Pancreatic islet allografts pretreated in vitro with monoclonal Ia antibody and transplanted beneath the renal capsule result in normoglycemia beyond 100 days in streptozotocin-induced diabetic recipient mice that differ only at H-2 K, H-2 K + I, or H-2 K + I + D from the donors. Mice with established islet allografts are not tolerant of donor-specific skin or islet antigens, but rather reject donor skin grafts in an accelerated fashion. Established anti-Ia antibody pretreated islet allografts continue to express target antigens and remain susceptible to rejection after challenge with donor skin grafts.This publication has 16 references indexed in Scilit:
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