Prolonged effects of large‐dose methylprednisolone infusion in multiple sclerosis
- 30 June 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 30 (7) , 702
- https://doi.org/10.1212/wnl.30.7.702
Abstract
Three daily 1-gm doses of methylprednisolone were administered to 12 patients with multiple sclerosis. Granulocytes, lymphocytes, T and B lymphocytes, lymphocyte transformation in response to several mitogens and one antigen, plasma cortisol, and serum IgM and IgA all returned to baseline within a few days. However, total white blood count, unstimulated lymphocyte incorporation of 3H-thymidine, hematocrit, serum IgM, and cerebrospinal fluid IgG synthesis remained altered 1 week after the infusion. The relationship of these changes to any clinical effects is unknown.This publication has 6 references indexed in Scilit:
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