The Therapeutic Effect of Lithium Carbonate on a Patient with a Forty-Eight Hour Periodic Psychosis

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Abstract
The almost complete therapeutic response of a patient with a forty-eight hour manic depressive illness to 500 mg. of lithium carbonate twice daily is presented. The response is dose-dependent and seems to be reduced by increased dietary sodium. After three years successful therapy the affective illness still returned with placebo administration. Continuous lithium treatment for the three years also caused a reversible depression of thyroid function, which treated with thyroxine.