Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in chronic pain patients
- 1 May 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Pain
- Vol. 33 (2) , 169-172
- https://doi.org/10.1016/0304-3959(88)90087-5
Abstract
Concentrations of somatostatin-like immunoreactivity in cerebrospinal fluid were significantly reduced in chronic pain patients compared to control patients without chronic pain. This difference was not influenced by demographic or clinical characteristics. Somatostatin has been shown to be a neurotransmitter in animal nociception; pharmacologic doses of this substance have moderated human pain. Our findings provide evidence that somatostatin may be involved in the pathogenesis of the chronic pain state.This publication has 16 references indexed in Scilit:
- Alterations in Cerebrospinal Fluid Concentrations of Somatostatinlike Immunoreactivity in Neuropsychiatric DisordersArchives of General Psychiatry, 1986
- Cerebrospinal Fluid Vasopressin, Oxytocin, sopressin, Oxytoc in Alzheimer's Diseasβ-EndorphinArchives of General Psychiatry, 1986
- Intrathecal somatostatin in terminally ill patients. A report of two casesPain, 1985
- Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal hornBrain Research, 1985
- Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivityNeuroscience Letters, 1984
- Distribution and origin of bombesin, substance P and somatostatin in cat spinal cordPeptides, 1983
- CSF Somatostatin in Affective IllnessArchives of General Psychiatry, 1983
- The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous systemNeuroscience, 1981
- Endorphins in chronic pain. I. Differences in CSF endorphin levels between organic and psychogenic pain syndromesPain, 1978
- The McGill Pain Questionnaire: Major properties and scoring methodsPain, 1975