Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

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Abstract
SPECIFIC AIMSIncreased brain oxidative stress is an early event in Alzheimer’s disease (AD) and has been implicated in its pathogenesis. The aim of the present study was to evaluate the effects of an antioxidant therapy (vitamin E) on the AD-like amyloidosis phenotype of a transgenic mouse model (Tg2576) when given before or after amyloid plaques are deposited.PRINICPAL FINDINGS1. Dietary vitamin E reduces brain oxidative stressStarting at 5 months of age, a group of Tg2576 mice was randomized to receive placebo or vitamin E (2 I.U./g diet) added to the regular diet. Considering a mouse eats ∼4–5 g chow/day and that the diet contained 2 I.U. of vitamin E per gram, the estimated average vitamin intake for each mouse was ∼8 I.U./day. At the end of the study, body weight, total plasma cholesterol, and triglyceride levels were not different between the two groups (not shown). Compliance with vitamin E intake was evident from the rise in plasma levels (20±2.1 vs. 47±1.9 μM, P<0.01) in mice receiving the supple...
Funding Information
  • Alzheimer's Association (IIRG 02‐0410)
  • American Heart Association (30211N)
  • National Institutes of Health (AG‐11542, ES11475)