THE EFFECT OF CHOLESTYRAMINE AND COLESTIPOL ON THE ABSORPTION OF HYDROCHLOROTHIAZIDE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 20  (4) , 151-154
Abstract
Cholestyramine and colestipol are nonabsorbable anionic exchange resins that are primarily used for lowering total and LDL [low density lipoprotein] cholesterol in patients with type II hyperlipoproteinemia.. The absorption of a variety of anionic drugs may also be decreased because of binding to the resins in the gastrointestinal tract. The effect of cholestyramine and colestipol on the absorption of a single orally administered dose of 75 mg hydrochlorothiazide was determined. Both urinary excretion and plasma levels of hydrochlorothiazide were measured. Cholestyramine or colestipol administration decreased the total urinary excretion of hydrochlorothiazide by 85 and 43%, respectively. Similar effects were also noted on plasma hydrochlorothiazide levels.

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