Cell signalling pathways involved in the regulation of vascular smooth muscle contraction and relaxation

22 February 1996

book chapter
Published by Oxford University Press (OUP)

p. 160-183
https://doi.org/10.1093/acprof:oso/9780192623874.003.0007

Abstract

A vast array of agonists regulate smooth muscle function by interacting with specific receptors located upon the cell membrane. This results in the activation of intracellular signalling pathways and the formation of a number of key second messengers. This chapter reviews recent studies implicating a role for protein kinase C (PKC) and tyrosine kinase pathways in regulating smooth muscle contraction and the involvement of cyclic nucleotide generating systems in relaxation.

Keywords

CELL SIGNALING PATHWAYS
VASCULAR SMOOTH MUSCLE
CONTRACTION
RELAXATION
PROTEIN KINASE C
TYROSINE KINASE
CYCLIC NUCLEOTIDES

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