Occurrence of selective ritonavir nonadherence and dose-staggering in recipients of boosted HIV-1 protease inhibitor therapy.
- 1 June 2009
- journal article
- research article
- Published by Taylor & Francis in HIV Research & Clinical Practice
- Vol. 10 (3)
- https://doi.org/10.1310/hct1003-135
Abstract
The inhibitory effect of ritonavir on hepatic cytochrome P450 enzymes is a critical factor in achieving optimal levels of co-administered "boosted" protease inhibitors (PIs). Even though nonadherence to antiretroviral medications is a common phenomenon, the prevalence of selective ritonavir nonadherence and dosestaggering (i.e., separating ritonavir and boosted PI doses in time) are unknown.Keywords
This publication has 10 references indexed in Scilit:
- Differential adherence to combination antiretroviral therapy is associated with virological failure with resistanceAIDS, 2008
- HIV-Infected Patients Receiving Lopinavir/Ritonavir-Based Antiretroviral Therapy Achieve High Rates of Virologic Suppression Despite Adherence Rates Less Than 95%JAIDS Journal of Acquired Immune Deficiency Syndromes, 2007
- A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 058 FIRST Study): a long-term randomised trialThe Lancet, 2006
- Selective Drug Taking During Combination Antiretroviral Therapy in an Unselected Clinic PopulationJAIDS Journal of Acquired Immune Deficiency Syndromes, 2005
- Patterns of adherence to antiretroviral medicationsAIDS, 2003
- Effect of simultaneous versus staggered dosing on pharmacokinetic interactions of protease inhibitorsClinical Pharmacology & Therapeutics, 2003
- Antiretroviral Therapy Adherence and Viral Suppression in HIV‐Infected Drug Users: Comparison of Self‐Report and Electronic MonitoringClinical Infectious Diseases, 2001
- Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV InfectionAnnals of Internal Medicine, 2000
- Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG Adherence InstrumentsAIDS Care, 2000
- The extent of non-adherence in a large AIDS clinical trial using plasma dideoxynucleoside concentrations as a markerAIDS, 1998