Characterization and inhibition of a cholecystokinin-inactivating serine peptidase
- 1 April 1996
- journal article
- Published by Springer Nature in Nature
- Vol. 380 (6573) , 403-409
- https://doi.org/10.1038/380403a0
Abstract
A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. Butabindide, a potent and specific inhibitor, was designed and shown to protect endogenous cholecystokinin from inactivation and to display pro-satiating effects mediated by the CCKA receptor.Keywords
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