Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway
- 1 April 1980
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 39 (4) , 835-839
- https://doi.org/10.1128/aem.39.4.835-839.1980
Abstract
A new blocked mutant of Aspergillus parasiticus produces no detectable aflatoxin B1, but accumulates several polyhydroxyanthraquinones. One of these pigments was identified as averantin. This is the first report of its formation by A. parasiticus. Radiotracer studies with [14C]averantin showed that 15.3% of label from averantin was incorporated into aflatoxin B1. This incorporation was blocked by dichlorvos. With radiotracers and other mutants, averantin was placed after norsolorinic acid and before averufin in the biosynthetic pathway in which the general steps are norsolorinic acid leads to averantin leads to averufin leads to versiconal hemiacetal acetate leads to versicolorin A leads to sterigmatocystin leads to aflatoxin B1.This publication has 21 references indexed in Scilit:
- Nuclear magnetic resonance identification of versiconal hemiacetal acetate as an intermediate in aflatoxin biosynthesisJournal of Agricultural and Food Chemistry, 1977
- Carbon-13 nuclear magnetic resonance studies of fungal metabolites, aflatoxins, and sterigmatocystinsThe Journal of Organic Chemistry, 1977
- Biosynthesis of aflatoxin. Conversion of norsolorinic acid and other hypothetical intermediates into aflatoxin B1Journal of Agricultural and Food Chemistry, 1976
- Biosynthesis of aflatoxin B1. Conversion of versicolorin A to aflatoxin B1 by Aspergillus parasiticusJournal of Agricultural and Food Chemistry, 1976
- Synthesis of versicolorin A by a mutant strain of Aspergillus parasiticus deficient in aflatoxin productionJournal of Agricultural and Food Chemistry, 1975
- Conversion of sterigmatocystin to aflatoxin B1 byBiochemical and Biophysical Research Communications, 1973
- Averufin in the biosynthesis of aflatoxin B1Journal of the American Chemical Society, 1973
- Isolation of averufin from a mutant of Aspergillus parasiticus impaired in aflatoxin biosynthesisBiochemical and Biophysical Research Communications, 1972
- Studies in mycological chemistry. Part XIX. “Product B”(averantin)[1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)anthraquinone], a pigment from Aspergillus versicolor(vuillemin) tiraboschiJournal of the Chemical Society C: Organic, 1966
- Incorporation of labelled compounds into aflatoxins☆Biochimica et Biophysica Acta (BBA) - General Subjects, 1964