EFFECT OF PARTIAL-HEPATECTOMY ON THE RESPONSE OF RAT-LIVER TO AFLATOXIN-B1

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (12) , 4739-4743
Abstract
The effect of partial hepatectomy (PH) on aflatoxin B1 (AFB1) action in rat liver was examined using adult male Fischer 344 rats. The elevated levels of hepatic DNA synthesis, present 26 h after PH (> 15 times the control level) and 33 h after PH, are rapidly inhibited by i.p. administration of AFB1. The percentage inhibitions are greater than those observed using intact or sham-operated animals. It was possible to demonstrate elevation of DNA synthesis in PH rats treated with AFB1. Rats 2 h after being treated with AFB1 (0.075 mg/kg) at 24 and 31 h after PH exhibited levels of DNA synthesis 380-400% of those present in sham-operated uninjected controls. After 62 wk, the livers of the PH rats treated with AFB1 displayed no hepatocellular carcinoma. There was an increased incidence of lesions believed to be preneoplastic. The differences between the long-term effects of AFB1 and other hepatocarcinogens on the livers of PH rats are discussed in terms of their relative capacities and modes of action in inhibiting DNA synthesis.

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