Corticatic Acids D and E, Polyacetylenic Geranylgeranyltransferase Type I Inhibitors, from the Marine Sponge Petrosia corticata
- 8 August 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 65 (9) , 1353-1356
- https://doi.org/10.1021/np020080f
Abstract
Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosiacorticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compounds 1−3 inhibited GGTase I from Candida albicans with IC50 values of 1.9−7.3 μM.Keywords
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