Detecting groups of co-evolving positions in a molecule: a clustering approach
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 7 (1) , 242
- https://doi.org/10.1186/1471-2148-7-242
Abstract
Although the patterns of co-substitutions in RNA is now well characterized, detection of coevolving positions in proteins remains a difficult task. It has been recognized that the signal is typically weak, due to the fact that (i) amino-acid are characterized by various biochemical properties, so that distinct amino acids changes are not functionally equivalent, and (ii) a given mutation can be compensated by more than one mutation, at more than one position.Keywords
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