Bacteriostatic Actions of Three Thiazol Derivatives of Sulfanila-mide upon Bacteria in Broth Cultures

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Abstract
Summary Three new thiazol derivatives of sulfanilamide have been studied with respect to their bacteriostatic action upon microorganisms. These compounds were found to be superior to sulfanilamide and sulfapyridine in their inhibitory actions upon pneumo-cocci Types I, II and III and beta Streptococcus hemolyticus Group A in concentrations as low as 5 mg %. Concentrations of 1 mg % proved the new derivatives to be more effective against the gono-coccus than the parent compound and sulfapyridine. The methyl and phenyl derivatives were found to be markedly bacteriostatic for Staphylococcus aureus. Sulfanilamide and sulfapyridine exhibited a moderate degree of inhibition upon the latter organism.

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