Concentration of substance P‐like immunoreactivity (SPLI) in tissues of dog, rat and mouse1
- 1 July 1981
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 112 (3) , 305-312
- https://doi.org/10.1111/j.1748-1716.1981.tb06821.x
Abstract
The distribution of SPLI in various tissues from dog, rat and mouse was determined by radioimmunoassay. The gastrointestinal, urogenital and tracheobronchial tracts contained SPLI with marked differences in levels in different parts of these tracts. Glandular tissues such as salivary glands and pancreas, as well as eye, tongue and skin contain SPLI. Species differences were encountered both in absolute amounts and the distribution of SPLI. The highest concentrations of SPLI were generally found in mouse followed by dog and rat. Results agree with those of previous studies in which SP was demonstrated by bioassay technique, but the greater sensitivity of the radioimmunoassay showed a much wider distribution of SP. Virtually all organs in which an effect of SP has been demonstrated also contain SPLI.Keywords
This publication has 42 references indexed in Scilit:
- Immunohistochemical evidence for substance P immunoreactive nerve fibres in the taste buds of the catActa Physiologica Scandinavica, 1979
- Substance P stimulation of amylase release by isolated parotid cells and inhibition of substance P induction of salivation by vasoactive peptidesMolecular and Cellular Endocrinology, 1979
- Biological activity and enzymic degradation of substance P analogs: Implications for studies of the substance P receptorBiochemical and Biophysical Research Communications, 1979
- Substance P release from spinal cord slices by capsaicinLife Sciences, 1979
- Substance P in rat CNS and duodenum during developmentBrain Research, 1979
- Localization of substance P-like immunoreactivity in nerves in the tooth pulpPain, 1977
- Opiate analgesics inhibit substance P release from rat trigeminal nucleusNature, 1977
- Hypothalamic hormones. 71. Synthesis and some biological activities of the tyrosine-8 analog of substance PJournal of Medicinal Chemistry, 1976
- Excitatory action of hypothalamic substance P on spinal motoneurones of newborn ratsNature, 1974
- Über den Einfluss der Kettenlänge bei C-terminalen Sequenzen der Substanz P — in Vergleich mit analogen Physalaemin- und Eledoisin-Peptiden—auf die Wirksamkeit am Meerschweinchen-IleumCellular and Molecular Life Sciences, 1974