The Use of Alkylmethylmorpholine-Based Background Electrolytes in Capillary Electrophoresis

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Abstract
A homologous series of alkylmethylmorpholinium hydroxides has been synthesized, characterized and used as the source of cationic co-ions in mobility-matching background electrolytes designed to eliminate the efficiency-degrading effects of electromigration dispersion. The mobilities of the co-ions vary over the 25∗10−5 to 45∗10−5 cm2/Vs range in 25 mM mobility-matching background electrolytes, prepared from phosphoric acid and the respective alkylmethylmorpholinium hydroxides. It was demonstrated experimentally that electromigration dispersion-related extra peak broadening could be minimized and difficult electrophoretic separations could be realized when these alkylmethylmorpholinium cations were used as co-ions.