Re: Characterization of hereditary nonpolyposis colorectal cancer families from a population-based series of cases.

Abstract
Peel et al. (1) have reported a low frequency of mismatch repair (MMR) gene defects in a population-based series of colorectal cancers. Previously, we determined the incidence of hereditary nonpolyposis colorectal cancer (HNPCC) by family history of colorectal cancer in a population-based series of colorectal cancers (2).