ALLOXAN DIABETES IN THE DOG1
- 1 November 1943
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 33 (5) , 297-308
- https://doi.org/10.1210/endo-33-5-297
Abstract
Intraven. administration of alloxan to dogs in a single dose exceeding 100 mg./kg. caused death of the animals within a few hrs. A dose between 75 and 100 mg./kg. produced a diabetic-uremic syndrome of which the animals died within 1 week. A dose of 50-75 mg./kg. produced typical diabetes without renal lesions. These animals could be kept alive for weeks." The main histologic features were a disappearance of the B cells from the islets, profound vacuolation of the pancreatic duct epithelium, and fatty changes of the liver. Doses of 25 mg./kg. were without effect.This publication has 2 references indexed in Scilit:
- Observations with differential stains on human islets of Langerhans1941
- Diabetes mellitus nach PankreasexstirpationNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1890