PORTAL CIRRHOSIS ASSOCIATED WITH CHRONIC INORGANIC ARSENICAL POISONING

9 June 1928

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 90 (23) , 1856-1859
https://doi.org/10.1001/jama.1928.02690500018003

Abstract

The well recognized toxic effect of arsenic on the liver has been the source of great concern to those employing the substance therapeutically. The introduction of organic arsenic compounds in the treatment of syphilis has been accompanied by an increase in the prevalence of jaundice following the treatment, and it is difficult to escape the conclusion that arsenical injury of the liver is responsible for at least a part of this increase. The possibility that inorganic arsenical compounds may injure the liver has been almost disregarded in present-day consideration of the etiology of portal cirrhosis. We shall review the literature on the subject and present two cases in which portal cirrhosis with ascites was associated with chronic arsenical poisoning. The occurrence of general anasarca following the ingestion of arsenic is recorded in the writings of Bang¹in 1774. Geyer,²in 1898, reported the occurrence of wholesale poisoning from

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