STIMULATION OF PROSTACYCLIN BIOSYNTHETIC ACTIVITY BY ESTRADIOL IN RAT AORTIC SMOOTH-MUSCLE CELLS IN CULTURE
- 1 January 1980
- journal article
- research article
- Vol. 619 (1) , 107-118
Abstract
Effects of estradiol on cell proliferation and prostacyclin biosynthetic activity in cultured rat aortic smooth muscle cells are investigated. Prostacyclin is the major product formed from arachidonic acid by the cells, in a cell-free homogenate system and in intact cells. When cells are treated with estradiol, no effect on cell proliferation is observed but a significantly stimulatory effect on prostacyclin biosynthetic activity in cells is evident. The maximal effect of estradiol on the stimulation of prostacyclin biosynthetic activity is observed after 5 day treatment of the cells with estradiol at its physiological concentration (10-9 M). Estradiol would be a protective hormone in atherosclerotic heart disease.This publication has 12 references indexed in Scilit:
- Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblastsCell, 1979
- Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbitsAtherosclerosis, 1978
- Gonadal hormones and pathogenesis of occlusive arterial thrombosisAmerican Journal of Physiology-Heart and Circulatory Physiology, 1978
- Synthesis of prostaglandin 6-keto F1α by cultured aortic smooth muscle cells and stimulation of its formation in a coupled system with platelet lysatesProstaglandins, 1978
- Metabolism of prostaglandin endoperoxide in animal tissuesProstaglandins, 1977
- Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxidesProstaglandins, 1976
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976
- Role of prostaglandin E in carrageenin-induced inflammation in ratsBiochemical Pharmacology, 1976
- Quantitation of apolipoprotein A-I of human plasma high density lipoproteinMetabolism, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951