Clinical Use of a New Membrane Oxygenator

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Abstract
A new oxygenator, developed by Shiley Laboratories, uses microporous polypropylene membrane material in a parallel plate design. The device has an integral heat exchanger and built-in temperature ports.The M-2000 oxygenator was used for routine cardiopulmonary bypass ( CPB) during open heart surgery on sixteen consenting adult patients. Mean age of the group was 56 years and the mean body surface area was 1.77m2. One patient had an atrial septal defect repaired, nine had coronary bypass, five had valve replacement and one, a valve replacement with coronary bypass. The average CPB time was 105 minutes.The circuit was primed with 2000 ml of balanced electrolyte solution and 500 ml of 6% hydroxyethyl starch in 0.9% saline to which 1500 units of heparin had been added.Average normothermic blood gas values were; PaO2=242 mm Hg, PaCO2=32.5 mmHg. During hypothermia the temperature corrected mean values were; PaO2=155 mm Hg and PaCO2=31 mm Hg. Hematological changes observed were hematocrit and hemoglobin concentrations decreased 33% due to dilution. Platelet counts decreased 46%. Plasma hemoglobin values increase a by 19.6 mg/dl.The M-2000 presented no problems to the investigators during this study. It exchanged gases in a satisfactory manner and is gentle in its blood handling properties.

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