The Age-Related Increase in Arterial Stiffness Is Augmented in Phases According to the Severity of Hypertension
Open Access
- 1 January 2004
- journal article
- Published by Japanese Society of Hypertension in Hypertension Research
- Vol. 27 (7) , 465-470
- https://doi.org/10.1291/hypres.27.465
Abstract
Although blood pressure and age are major determinants of arterial stiffness, it is still unclear whether age-related changes in arterial stiffness are similar among subjects with different degrees of severity of hypertension. The present study examined the association between age and pulse wave velocity in subjects with different degrees of hypertension stratified according to the JNC-7 classification (Normal, Prehypertensive, and Stage I or II Hypertensive subjects). A number of 5,312 subjects (age range, 30-79 years) with no atherosclerotic risk factors other than high blood pressure were selected from two cohorts who regularly underwent annual health checkups, including the measurement of brachial-ankle pulse wave velocity (baPWV). baPWV was increased according to the severity of hypertension in all age groups. The association between age and baPWV formed a quadratic curve in each stage in both genders. The steepness of the slope of the quadratic curve increased according to the severity of hypertension. In each stage of hypertension, age and the baPWV were divided into tertiles. After adjustment for systolic and diastolic blood pressure, the odds ratio of having an increased baPWV in the 3rd age tertile (the highest-age group) was found to increase according to the severity of hypertension. In conclusion, the age-related increase of baPWV was shown to be augmented in phases according to the severity of hypertension, and this augmentation occurred even between the Normal and Prehypertensive stages. These results support the JNC-7 recommendations for a strict control of blood pressure even in the elderly. (Hypertens Res 2004; 27: 465-470)Keywords
This publication has 22 references indexed in Scilit:
- Current Perspectives on Arterial Stiffness and Pulse Pressure in Hypertension and Cardiovascular DiseasesCirculation, 2003
- Echogenic Carotid Plaques Are Associated With Aortic Arterial Stiffness in Subjects With Subclinical Carotid AtherosclerosisHypertension, 2003
- Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12 517 subjectsAtherosclerosis, 2003
- Brachial-Ankle Pulse Wave Velocity as a Marker of Atherosclerotic Vascular Damage and Cardiovascular RiskHypertension Research, 2003
- Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose IntoleranceCirculation, 2002
- Validity, Reproducibility, and Clinical Significance of Noninvasive Brachial-Ankle Pulse Wave Velocity Measurement.Hypertension Research, 2002
- Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive PatientsHypertension, 2001
- Pulse pressure—a review of mechanisms and clinical relevanceJournal of the American College of Cardiology, 2001
- Assessment of Arterial Distensibility by Automatic Pulse Wave Velocity MeasurementHypertension, 1995
- Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China.Circulation, 1985