GALACTOSE DISAPPEARANCE FROM THE BLOOD STREAM. CALCULATION OF A GALACTOSE REMOVAL CONSTANT AND ITS APPLICATION AS A TEST FOR LIVER FUNCTION
Open Access
- 1 September 1946
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 25 (5) , 768-775
- https://doi.org/10.1172/jci101761
Abstract
The rate of disappearance of galactose from the blood stream after intraven. injn. of 0.5 mg./kg. was studied in normal adults, patients with Laennec''s cirrhosis of the liver, chronic passive congestion of the liver, hepatitis, and other affections of the liver, with and without functional impairment. The % of galactose removed/min. is termed the galactose removal constant. This is calculated as follows: n-o r 2.3 (log Cl - log C2) X 100 G.R.C. = W^ti Where C1 and C2 are the concns. in blood galactose (mg./100 ml.) at the times t1 and t2 expressed in mins. following the injn. The galactose removal constant varied between 4.2 and 9.5 in the control group, whereas it was below 4 in patients with impaired liver functions. There was a good correlation between the changes in the galactose removal constant and tests pertaining to other liver functions.Keywords
This publication has 2 references indexed in Scilit:
- KINETICS OF THE DISAPPEARANCE OF GALACTOSE FROM THE PLASMA AFTER A RAPID INTRAVENOUS INJECTIONAmerican Journal of Physiology-Legacy Content, 1944
- THE INTERMEDIARY METABOLISM OF FRUCTOSE AND GALACTOSEPhysiological Reviews, 1936