VARIABLES DISCRIMINATING BETWEEN CRYPTOGENIC GLOMERULAR LESIONS IN ADULTS WITH NEPHROTIC SYNDROME

  • 1 January 1976
    • journal article
    • research article
    • Vol. 45  (179) , 451-468
Abstract
A univariate analysis of individual clinical and biochemical values of adult patients with cryptogenic nephrotic syndrome showed that significant differences existed between patients with proliferative glomerulonephritis, minimal change nephritis and membranous nephropathy. For any given adult patient with the condition, the most likely clinical diagnosis is proliferative disease and the next, minimal change. These 2 diagnoses together accounted for most cases. The best clinical discriminants between them were the systolic blood pressure and plasma cholesterol concentration. If the systolic pressure was greater than 145 mm Hg, proliferative disease was more likely, but if the cholesterol was greater than 530 mg/100 ml, a minimal change lesion was more likely. A scattergram for combining these variables in clinical practice was given, showing a zone of uncertainty where renal biopsy would be indicated.

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