Nα-2-Mercaptobenzylamine-Assisted Chemical Ligation
- 14 December 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (1) , 23-26
- https://doi.org/10.1021/ol991184t
Abstract
The selective formation of an amide bond in the presence of unprotected functional groups is a challenging problem of peptide chemistry. A 2-mercaptobenzyl group tethered at the N-terminus of model peptides was observed to facilitate amide bond formation when a peptide thioester was added under mild aqueous conditions.Keywords
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