O-Perfluoroalkylation of 4-hydroxyphenylglycine
- 1 January 1993
- journal article
- Published by Springer Nature in Amino Acids
- Vol. 5 (1) , 99-101
- https://doi.org/10.1007/bf00806196
Abstract
Racemic N-Boc-4-difluoromethoxyphenylglycine was prepared by O-difluoromethylation of D-N-Boc-4-hydroxyphenylglycine under basic conditions, whereas the hexafluoropropylation reaction gives optically pure D-N-Boc-4-hexafluoropropoxyphenylglycine. D,L-4-difluoromethoxyphenylglycine was obtained by the action of TFA on the corresponding amino acid derivative.Keywords
This publication has 0 references indexed in Scilit: