Protective Effect of 2-Diethylaminoethyl 4-Methylpiperazine-1-Carboxylate in Mice Infected with Influenza Virus

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Abstract
Summary 2-Diethylaminoethyl 4-methylpiperazine-1-carboxylate given orally protected a significant number of mice from the lethal effect of infections with strains of influenza A, A1, and A2. The compound was effective only when given immediately before or after infection. The compound did not inactivate the virus on contact in vitro, but in mice it held the virus concentration in the lungs at about one-tenth that reached in controls. Mice protected by the piperazinecarboxylate from an influenza infection were immune to a subsequent challenge with the same virus. The piperazinecarboxylate was more active than 1-adamantanamine against the PR-8 strain of virus, but less active than 1-adamantanamine against the Jap 305/57 strain and the Ann Arbor 1/57 strain. Neither of the 2 compounds was effective against strains of influenza B. Mixtures of the piperazinecarboxylate and of 1-adamantanamine were more effective in the influenza A (PR-8) infection than either of the compounds given alone.

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