The Mechanism(s) of Hypoxic Pulmonary Vasoconstriction: Potassium Channels, Redox O2Sensors, and Controversies
- 1 August 2002
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 17 (4) , 131-137
- https://doi.org/10.1152/nips.01388.2002
Abstract
Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in Po2are sensed by a vascular redox O2sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K+channels, thereby controlling membrane potential, Ca2+entry, and tone.Keywords
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