Cyclic AMP and the preparation of the mouse uterus for implantation

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Abstract
Experiments are described that demonstrate the ability of dibutyryl cyclic AMP (dcAMP) to induce estrogen-like changes in the uteri of ovariectomized mice treated with progesterone. A single intraluminal injection of 6.14 .mu.g dcAMP in 0.02 ml phosphate-buffered saline promoted cell division in the uterine stroma and sensitized the endometrium, so that a decidual reaction could be induced by a subsequent injection of arachis oil into the uterine lumen. Since dcAMP has already been shown to induce implantation of diapausing mouse blastocysts in the absence of estrogen, cAMP is probably involved in egg implantation in rodents.

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