The effect of substrates and inhibitors on the rate of respiration of the infective larvae of Strongyloides ratti Sandground, 1925

Publisher Website
Google Scholar
Abstract
The infective larvae of S. ratti were non-feeding and none of a wide variety of possible substrates had any effect on the respiratory rate of intact worms. Sodium succinate increased the oxygen uptake of larval homogenates.The cytochrome chain inhibitors, sodium cyanide, sodium azide and urethane all reversibly inhibited the respiration of the infective larvae. The inhibition caused by carbon monoxide was photo-reversible and 2,4-dinitrophenol inhibited respiration rather than stimulated it. Methylene blue increased the oxygen uptake of homogenates, but had no effect on the intact larva. Iodoacetamide and sodium arsenite irreversibly inhibited respiration, whilst sodium fluoride, sodium pyrophosphate and sodium malonate were without effect on the intact larvae.This work was carried out during the tenure of a Medical Research Council Scholarship.